|
English name: Fenugreek
Sanskrit name:
Methika
Family: Leguminosae
Part used: Seeds, Leaves,
Entire plant
| Extraction
method: |
CO2
extracts | Solvent extracts
Fortified extracts | Whole herb extracts |
More
info |
Traditional
uses: "Fenugreek is an esteemed medicine
in North Africa, the Middle East, and India, being used
for a wide variety of conditions. The nourishing seeds
are given during convalescence and to encourage weight
gain, especially in anorexia.
Helpful in lowering fever, it is compared to quinine
by some authorities. The seeds’ soothing effect
makes them of value in treating gastritis and gastric
ulcers.
They are used to induce childbirth and to increase breast-milk
production. They are also used to lower blood sugar
and blood cholesterol levels. Externally, the seeds
are applied as a paste to treat abscesses, boils, ulcers,
and burns, or used as a douche for excessive vaginal
discharge. The seeds freshen bad breath and help restore
a dulled sense of taste. The oil in the seeds is used
as a skin softener and emollient.
In China, the seeds are used as a pessary to treat cervical
cancer. In the Middle East and the Balkans, the aerial
parts are a folk remedy for abdominal cramps associated
with both menstrual pain and diarrhea or gastroenteritis.
They are also used to ease labour pains. Herbalists
in Asia and the Mediterranean often recommend fenugreek
to stimulate contractions in delayed or sluggish labour.
"
Phytochemistry:
The plant contains a number of steroidal sapogenins,
specially diosgenin found in the oily embryo. Two furastanol
glycosides, F-ring opened precursors of diosgenin have
been reported, as also hederagin glycosides. The alkaloid
trigonelline, trigocoumarin, trimethyl coumarin and
nicotinic acid are also present. Mucilage is a prominent
constituent of the seeds.
Pharmacology:
"The seeds of this commonly used spice contain
about 50 percent fiber, of which 20 percent is mucilaginous
fiber similar to guar gum, which is a known hypoglycemic
agent. The protein fraction of the seeds contains the
amino acid 4-hydroxyleucine which has been proven to
timulate insulin production. Saponins present in fenugreek
seeds have also been shown to lower cholesterol levels
in human subjects. Recent studies have revealed the
efficacy of defatted fenugreek seed extracts in the
anagement of both Type I and Type II diabetes. Administration
of defatted fenugreek seed powder for a period of three
weeks significantly improved the performance of Type
II diabetes patients in the glucose tolerance test.
Additional beneficial effects included lowered urinary
sugar and reduced serum cholesterol levels. Some of
the patients under treatment also reduced their insulin
requirements from 56 units per day to 20 units per day.
This effect was found to be sustained and lasting with
no undesirable side effects. Within the duration of
this study, there were no new incidences of heart problems
such as angina and myocardial infarction and no increases
in blood pressure, indicating that fenugreek may be
helpful in preventing the secondary complications of
diabetes such as hyperlipidemia and therosclerosis."
Marker constituents: Tribulosin,
Saponins.
Specification: Total Saponins
(%w/w) – 50%
| SL NO |
TESTS |
LIMITS |
PROTOCOL |
| 1. |
Description
|
Brown to yellowish brown
hygroscopic powder |
| 2. |
Physico-chemical analysis |
|
|
| Moisture (%w/w) |
< 9.0 |
As per USP <921> Method II |
| 3. |
Particle Size |
|
|
Bulk Density (g/cc)
|
0.20 – 0.80 |
As per USP <616> Method –
I |
| Tapped bulk density |
0.25 – 0.95 |
| Material passing through 30# BS/35 ASTM (%w/w) |
> 99.0 |
As per USP <786>
Particle Size distribution. |
| 4. |
Heavy metal analysis |
|
AAS / ICP –ES |
| Lead |
< 10.0 ppm |
| Cadmium |
< 1.0 ppm |
| Arsenic |
< 2.0 ppm |
| Mercury |
< 0.1 ppm |
| 5. |
Microbiological analysis |
|
As per HO/PHARMA/
92.559/Rev.1 Pg.49-52 |
| As per FIP Guidelines |
|
| Total Viable Aerobic Count |
< 104 cfu g-1 |
| Total Enterobacteriaceae |
< 102 org g-1 |
| Total Fungal Count |
< 102 fs g-1 |
| 6. |
Test for Specific Pathogen |
|
| As per FIP Guidelines |
Absent |
| E.coli (1g) |
| Salmonella Sp. (10g) |
| S.aureus (1g) |
| 7. |
Mycotoxin analysis |
< 5 ppb |
As per USP Test for Aflatoxins |
| Aflatoxins (B1 + B2 + G1 + G2) |
| 8. |
Residual solvent analysis |
<3000 ppm |
As per USP <467> |
| As per ICH Guidelines |
| Methanol |
| 9. |
Pesticide residue analysis |
To comply with
USP |
As per AOAC / USP. |
| As per USP & BP Limits |
| Organochlorine Pesticides |
| Organophosphorus Pesticides |
| Synthetic pyrethroids |
| 10. |
Phytochemical analysis |
> 50% |
By Gravimetry |
| Total Saponins (%w/w) |
|