English name: Paclitaxel
Plant : Taxus brevifolia
Classification : Taxanes
Type : Mitotic inhibitors
Molecular formula : C47H51NO14
Chemical Name : ß-(benzoylamino)-a-hydroxy-,6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,
5,6,9,10,11,
12,12a,12b-dodecahydro-4,11- dihydroxy-4a,8,13,13-tetramethyl-5-oxo-
7,11-methano-1H-cyclodeca(3,4)benz(1,2-b) oxet-9-ylester,(2aR-(2a-a,4-ß,4a-ß,6-ß,9-a
(a-R*,ß-S*),11-a,12-a,12a-a,2b-a))- benzenepropanoic
acid.
Molecular weight : 853.906
g/mol -
Chemical and Physical Index :
| Appearance |
White crystalline powder |
MP
|
210- 213 C (Decomposes) |
Solubility
|
DMSO, Methanol, Ethanol.
Unstable in Methanol.Insoluble in cold water, hot
water.Clear colorless solution at 10mg/ml of Methanol. |
Purity: 99.46%
Quality Standard :
As
|
<0.0001% |
Contents(HPLC)
|
100±2.0% |
Endotoxins
|
3.0% max |
Heavy Metal
|
<0.001% |
Loss of drying
|
=4.0 % |
Optical Rotation
|
It is -49° ~ -55° |
Solvent Residue
|
0.2% max |
Sulphated ash
|
= 0.2 % |
Storage : Store in cool
& dry place. Keep away from strong light and heat.Store
at -20°C.
Shelf life : Two years
when properly stored.
Usage : Intermediates/Pharmaceutical
intermediates
Image
:
Stability : Stable under
normal conditions.
|
