|
| Lagerstroemia speciosa
linn: |
|
English name : Queen's
Flower, Queen's Crepe Myrtle, Pride of India, Giant
Crepe Myrtle seeds
Sanskrit name:
Kramuka
Family :
Lythraceae
Part used : Leaves
Extraction
method: |
CO2
extracts | Fortified extracts
Solvent extracts | Whole herb extracts |
More
info |
 Phytochemistry:
ellagitannins, lagerstroemin, flosin B and reginin A
Pharmacology:
The blood sugar regulating properties of banaba
have been demonstrated in cell culture, animal and human
studies. In isolated cells, the active ingredient in
banaba extract, corosolic acid, is known to stimulate
glucose uptake. In diabetic mice, rats and rabbits,
banaba feeding reduces elevated blood sugar and insulin
levels to normal. In humans with type II diabetes, banaba
extract, at a dose of 16-48mg per day for 4-8 weeks,
has been shown to be effective in reducing blood sugar
levels (5%-30% reduction) and maintaining tighter control
of blood sugar fluctuations. An interesting “side-effect”
of tighter control of blood sugar and insulin levels
is a significant tendency of banaba to promote weight
loss (an average of 2-4 lbs. per month) – without
significant dietary alterations. It is likely that modulation
of glucose and insulin levels reduces total caloric
intake somewhat and encourages moderate weight loss.
Marker constituent: corosolic
acid
Specification: Corosolic
acid 1%
| SL NO |
TESTS |
LIMITS |
PROTOCOL |
| 1. |
Description
|
Green to greenish brown powder with
characteristic odour. |
| 2. |
Physico-chemical analysis
|
|
|
| Loss on drying (%w/w) |
< 8.0 |
As per USP <921> Method III |
| Total ash content (%w/w) |
< 5.0 |
As per USP <561> |
| pH of 1% w/v solution |
3.0 – 5.0 |
As per USP <791> |
| 3. |
Particle Size |
|
|
| Bulk Density (g/cc) |
0.25 – 0.90 |
As per USP <616> Method –
I |
| Tapped bulk density |
0.30 – 1.20 |
| Material passing through 30# BS/35 ASTM (%w/w) |
> 99.0 |
As per USP <786>
Particle Size distribution. |
| 4. |
Heavy metal analysis |
|
AAS / ICP –ES |
| Lead |
< 10 ppm |
| Cadmium |
< 1.0 ppm |
| Arsenic |
< 2.0 ppm |
| 5. |
Microbiological analysis |
|
|
| As per FIP Guidelines |
|
|
| Total Viable Aerobic Count |
< 104 cfu g-1 |
As per WHO/PHARMA/92.559/Rev.1 Pg.49-52 |
| Total Enterobacteriaceae |
< 102 org g-1 |
| Total Fungal Count |
< 102 fs g-1 |
| 6. |
Test for Specific Pathogen |
|
| As per FIP Guidelines |
|
| E.coli (1g) |
Absent |
| Salmonella Sp. (10g) |
Absent |
| S.aureus (1g) |
Absent |
| 7. |
Mycotoxin analysis |
|
As per USP Test for Aflatoxins |
| Aflatoxins (B1 + B2 + G1 + G2) |
5ppb |
| 8. |
Pesticide residue analysis |
To comply with USP |
As per AOAC / USP |
| As per USP & BP Limits |
| Organochlorine Pesticides |
| Organophosphorus Pesticides |
| Synthetic pyrethroids |
| 9. |
Phytochemical analysis |
1.0 |
By HPLC |
| Corosolic acid (%w/w) |
Specification: Corsolic
acid 2%
| SL NO |
TESTS |
LIMITS |
PROTOCOL |
| 1. |
Description
|
Green to greenish brown powder with
characteristic odour. |
| 2. |
Physico-chemical analysis
|
|
|
| Loss on drying (%w/w) |
< 8.0 |
As per USP <921> Method III |
| Total ash content (%w/w) |
< 5.0 |
As per USP <561> |
| pH of 1% w/v solution |
3.0 – 5.0 |
As per USP <791> |
| 3. |
Particle Size |
|
|
| Bulk Density (g/cc) |
0.25 – 0.90 |
As per USP <616> Method –
I |
| Tapped bulk density |
0.30 – 1.20 |
| Material passing through 30# BS/35 ASTM (%w/w) |
> 99.0 |
As per USP <786>
Particle Size distribution. |
| 4. |
Heavy metal analysis |
|
AAS / ICP –ES |
| Lead |
< 10 ppm |
| Cadmium |
< 1.0 ppm |
| Arsenic |
< 2.0 ppm |
| 5. |
Microbiological analysis |
|
|
| As per FIP Guidelines |
|
|
| Total Viable Aerobic Count |
< 104 cfu g-1 |
As per WHO/PHARMA/92.559/Rev.1 Pg.49-52 |
| Total Enterobacteriaceae |
< 102 org g-1 |
| Total Fungal Count |
< 102 fs g-1 |
| 6. |
Test for Specific Pathogen |
|
| As per FIP Guidelines |
|
| E.coli (1g) |
Absent |
| Salmonella Sp. (10g) |
Absent |
| S.aureus (1g) |
Absent |
| 7. |
Mycotoxin analysis |
|
As per USP Test for Aflatoxins |
| Aflatoxins (B1 + B2 + G1 + G2) |
5ppb |
| 8. |
Pesticide residue analysis |
To comply with USP |
As per AOAC / USP |
| As per USP & BP Limits |
| Organochlorine Pesticides |
| Organophosphorus Pesticides |
| Synthetic pyrethroids |
| 9. |
Phytochemical analysis |
2.0 |
By HPLC |
| Corosolic acid (%w/w) |
|
