Scientific name: Garcinia cambogia

Common names: Vilayti imli, citrin, gambooge, Brindal Berry, Gorikapuli, HCA, Hydroxycitric acid, Malabar Tamarind.

Sanskrit name: Vrikshamla, Kankusta

Family: Clusiaceae

Identification method: Positive for (-) Hydroxycitric Acid by HPLC

Color: Off white to pale brown powder

Odor: Characteristic odour

Taste: Salty herbal in taste

Bulk density: 0.6 to 0.8 g/ml

General Description: It is a small or medium-sized tree with a rounded crown and horizontal or drooping branches. The leaves are dark green, shining, elliptic to obovate. Fruits are ovoid, 2 inches in dia., yellow or red when ripe, with 6-8 grooves. Seeds are 6-8 surrounded by a succulent aril.

Traditional uses: Garcinia Cambogia is a relative new-comer to the ranks of Western herbalism, but has been used for thousands of years in the Orient as a food supplement. It is used as an appetite suppressant and to inhibit the absorption and synthesis of fat, cholesterol and triglycerides. In other words, it is a dietary aid. The leaves of this creeper are used as one of the most potent agents to counteract diabetes and also benefited in the treatment of obesity. In the Ayurvedic system of medicine, the flavors of Garcinia cambogia are said to activate digestion and are used as purgatives, in the treatment of worms and parasites, tumors and dysentery.

Phytochemistry: The fruit contains 30% acid (calculated as Citric acid) essentially (-)-hydroxy-citric acid. Camboginol and cambogin was also identified.

Pharmacology: Oral administration of (-)-hydroxy-citrate depressed significantly the weight, body lipid, and appetite in invivo lipogenic rats.

One of the factors for fat accumulation in the body is increased quantity of the key enzyme known as ATP - citrate lyase which facilitates the process of conversion of carbohydrates and sugars into fats and cholesterol. The fruit extract of Garcinia cambogia (containing 50% of HCA as the chief ingredient) competitively blocks ATP - citrate lyase enzyme making it ineffective which inturn hinders the production and storage of body fats. By inhibiting this enzyme, the fruit extract shifts the conversion of calories from fat to glycogen. This increased production of glycogen stimulates the glucoreceptors in the liver and sends satiety signals to the brain. Thus appetite and food craving are suppressed. Besides promoting glycogen production it also signals the Kreb's cycle to initiate betaoxidation which burns the body's stored fat. Thus the fruit extract containing highest concentration of HCA, promotes weight loss and assists the body's natural cycles in proper metabolism of fats. This has been verified by more than 20 years of research by the Pharmaceutical giant - Goffmann-La-Roche and others.

Marker constituent: Hydroxycitric acid

Main Uses: It is found useful for inhibiting lipogenesis, reducing the production of cholesterol and fatty acids, producing more glycogen in liver, increasing BMR or basal metabolic rate or increasing the production of heat in body by activating the process of thermogenesis, suppressing the appetite and encouraging weight loss.

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