|
English name: Turmeric
Sanskrit name: Haridra
Family: Zingiberaceae
Part used: Rhizomes
Extraction
method: |
CO2
extracts | Fortified extracts
Solvent extracts | Whole herb extracts |
More
info |
 Traditional
uses: The rhizomes are bitter, acrid, thermogenic
carminative emollient, anodyne, anti-inflammatory, vulnerary,
depurative, antiseptic, appetiser, stomachic, anthelmintic,
laxative, diuretic, expectorant, haematinic, alterative,
alexiteric, stimulant, febrifuge and tonic. It is useful
in vitiated conditions of kapha and pitta, inflammations,
ulcers, wounds, skin diseases, allergic conditions,
anorexia, dyspepsia, constipation, cough, anaemia, dropsy,
gonorrhea, amenorrhoea, jaundice and general debility.
Phytochemistry:
The major bioactive constituent of Curcuma longa
are a group of diferuloylmethanes known as “curcuminoids”,
which contains mainly curcumin along with desmethoxycurcumin
and bisdesmethoxycurcumin. The rhizome also contains
volatile oil consisting mainly of bisabolane derivatives;
polysaccharides viz. ukonan A, B, C and D common : phytosterols
and fatty acids.
Pharmacology:
Curcuma longa has been evaluated for various
pharmacological activities. Curcuma longa has been found
to be potent, anti-inflammatory, antirheumatic, antiarthritic
and wound healing activity. Curcuma longa is also been
reported for gastroprotective, antispasmodic, anticoagulant,
antifertility, hypolipidemic, antibacterial, antifungal
and antitumour activity.
Marker constituent: Curcumin
Main uses: Anti-inflammatory, antioxidant, food
colorant.
Specification:
10% Curcuminoids
| SL NO |
TESTS |
LIMITS |
PROTOCOL |
| 1. |
Description
|
Light yellow to light
brownish-yellow powder |
| 2. |
Physico-chemical analysis
|
|
|
| Moisture (%w/w) |
< 12.0 |
As per USP <921> Method II |
| Total ash content (%w/w) |
< 8.0 |
As per USP<561> |
| Acid insoluble Ash (%w/w) |
< 3.0 |
| 3. |
Particle Size |
|
|
| Bulk Density (g/cc) |
0.20 – 0.60 |
As per USP <616> Method –
I |
| Material passing through 30# BS/35
ASTM (%w/w) |
> 99.0 |
As per USP <786> Particle Size
distribution. |
| 4. |
Heavy metal analysis |
|
AAS / ICP –ES |
| Lead |
< 10 ppm |
| Cadmium |
< 1 ppm |
| Arsenic |
< 2 ppm |
| Mercury |
< 0.1 ppm |
| 5. |
Microbiological analysis |
|
As per WHO/PHARMA/92.559/Rev.1
Pg.49-52 |
| As per FIP Guidelines |
|
| Total Viable Aerobic Count |
< 104 cfug- |
| Total Enterobacteriaceae |
< 102 org g-1 |
| Total Fungal Count |
< 102 fs g-1 |
| 6. |
Test for Specific Pathogen |
|
| As per FIP Guidelines |
|
| E.coli (1g) |
Absent |
| Salmonella Sp. (10g) |
Absent |
| S.aureus (1g) |
Absent |
| 7. |
Mycotoxin analysis |
<5ppb |
As per USP Test for Aflatoxins |
| Aflatoxins (B1 + B2 + G1 + G2) |
| 8. |
Pesticide residue analysis |
To comply with
USP |
As per AOAC / USP |
| As per USP & BP Limits |
| Organochlorine Pesticides |
| Organophosphorus Pesticides |
| Synthetic pyrethroids |
| 9. |
Phytochemical analysis
|
> 10.0 |
By Spectrophotometry |
| Curcuminoids (%w/w) |
Note:
Residual solvent analysis and residual pesticide analysis
are performed only on request
| SL NO |
TESTS |
LIMITS |
RESULT |
TEST PROTOCOL |
| 1. |
Description |
Yellow to orange yellowish free flowing
powder |
Orange yellow free flowing powder |
- |
| 2. |
Identification |
To pass the test |
Positive for Curcumin and its derivatives |
By TLC
[NR/QCD/APM05 WI(10)] |
| 3. |
Moisture (%w/w)
|
< 1.0 |
0.4 |
As per USP <921> Method II |
| 4. |
Total ash content (%w/w)
|
< 0.5 |
0.1 |
As per USP <561> |
| 5. |
Volatile oil (%w/v) |
Volatile oil (%w/v)
<
2.0
|
1.9 |
As per USP <561> |
| 6. |
Bulk density (g/cc) |
0.20– 0.60 |
0.41
|
As per USP <616>
Method – I
|
| Tapped bulk density (g/cc) |
0.20– 0.90 |
0.50 |
| 7. |
Material passing through 30# BS/35
ASTM (%w/w) |
> 99.0 |
Complies |
As per USP <786>
Particle size distribution
|
8. |
Heavy Metals |
|
|
AAS / ICP –ES |
| Lead |
< 10 ppm |
< 0.1 |
| Arsenic |
< 3 ppm |
< 0.1 |
| Cadmium |
< 5 ppm |
< 0.1 |
| Mercury |
< 1 ppm |
< 0.1 |
| 9. |
Microbiology Test |
|
|
As per WHO/PHARM/
92.559/ Rev. 1, Pg. 49 |
| Total viable aerobic count |
< 104 cfu g-1 |
No growth |
| Total fungal count |
< 102 fs g-1 |
No growth |
| Total enterobacteriaceae |
< 1 org g-1 |
< 1 |
| E. coli |
Absent |
Not detected |
| Salmonella species |
Absent |
Not detected |
| S. aureus |
Absent |
Not detected |
| 10. |
Phytochemical Analysis |
|
|
|
| Total curcuminoids (% w/w) |
>= 95.0 |
96.3 |
By Spectrophotometry
[NR/QCD/APM06 WI(06)]
|
Remarks:
The above referred batch conforms to the specification
of Curcuma longa extract (>= 95% Curcuminoids)
with respect to above mentioned tests.
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