Name: Colchicine
Plant : Isolated from
Colchicum, Iphiginia spp. and Gloriosa superba. Chief
alkaloid from Colchicum autumnale, many other Colchicum
spp., several Merendera spp., Gloriosa superba and others
(Liliaceae).
Classification : Alkaloids
Synonym(s): Colchiceine
methyl ether. Artrichine. Colchisol. Colsaloid. NSC
757.
Molecular formula : C22H25NO6
Molecular weight : 399.45
g/mol
Chemical and Physical Index :
Solubility
|
Soluble in MeOH, C6H6, H2O;
fairly soluble in Et2O; poorly soluble in Hexane |
Melting point
|
155-157 degree celsius |
Purity: =98%
Quality Standard :
Concentration
|
1mCi/mL |
Contents(HPLC)
|
min. 98 % |
| Radionuclide |
3H |
| Specific Activity |
60-87Ci (2220-3219GBq)/mmol |
| Specific Rotation |
It is -240° to -250° |
| Sulphated ash |
max. 0.05 % |
Storage : "Susceptible
to oxidation and sensitive to exposure to light. It
immediately discolors on storage, but no radiochemical
impurity can be detected.Store at -20°C. LONG TERM
STORAGE: +4°C "
Usage : Antibiotic. Inhibitor
of microtubules by specific binding to tubulin. Induces
apoptosis.
Application notes : Antibiotic.
Inhibitor of microtubules by specific binding to tubulin.
Induces apoptosis.
Handling : Protect
from light and moisture.
Caution : Very Toxic.
Hazard Codes : T+
Package : Vial which
protects contents from UV light.
Shipping Information :
Shipped Ambient, Packaged in ethanol under nitrogen
in a vial that protects contents from UV light.
Stability: It immediately
discolors on storage, but no radiochemical impurity
can be detected.
|
