English name: Camptothecin
Molecular formula : C20H16N2O4
Chemical Name : 4(S)-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]
indolizino[1,2-b]quinoline-3,14 (4H,12H)-dione
Molecular weight : 348.4
Chemical and Physical Index :
Colour
|
It is light yellow
powder or light yellow crystalline powder. |
Solubility
|
It is soluble in DMSO (10 mg/ml).
It dissolves sparingly in Ethanol and Chloroform
etc and hardly in water. |
MP
|
260 degree celsius |
Purity: >98% by
TLC
Quality Standard :
As
|
<2ppm |
| Contents(HPLC) |
>98% |
Heavy Metal
|
<10ppm |
Loss of drying
|
<0.5% |
Sulphated ash
|
<0.1% |
 Storage
: Keep away from light in a tightly
sealed vial. Store powder at 0-4 degree celsius for
up to one year. Store solutions at -20oC for up to 3
months.
Usage :Pharmaceuticals
Intermediates
Application notes
: Reversibly inhibits
nuclear topoisomerase I by binding to and stabilizing
the topoisomerase-DNA covalent complex. Inhibits Tat-mediated
transcription of HIV-1. Induces apoptosis in Jurkat,
osteosarcoma and hepatoma cells.
Caution :
Potential mutagen/reproductive hazard!
Package
: According to customers' needs
Stability : The
product is stable.
Hazard Codes : T
|
