|
English name: Malabar
nut
Sanskrit name:
Vasaka
Family: Acanthaceae
Part used: Leaves
Extraction
method: |
CO2
extracts | Fortified extracts
Solvent extracts | Whole herb extracts |
More
info |
 Traditional
uses: The plant is recommended for a variety
of ailments such as bronchitis, asthma, fever, jaundice
etc. The leaves & roots are efficacious in coughs,
arthritis, diarrhoea & dysentery and have the best
haemostatic quality. Leaves are anti-inflammatory, analgesic,
effective in skin disorders, cardiotonic. This is one
of the most potent anti tuberculosis drug. Vasicine
is also reported for its anthelmintic and weak hypotensive
activity.
Phytochemistry:
The major bioactive constituent of Adhatoda vasica
is a pyrralazoquinoline alkaloid – vasicine. The
other alkaloids include vasicol, adhatonine, vasicinone,
vasicinol, vasicinolone etc. The other constituents
include aliphatic hydroketones viz., 37-hydroxyhexateracont-1-en-15-one
and 37-hydroxy hentetracontan-19-one; common phytosterols
viz., a-sitosterol and its D-glucose.
Pharmacology:
Adhatoda vasica has been evaluated for various pharmacological
activities. Adhatoda vasica has been found to be potent
bronchodilator and expectorant. Adhatoda vasica
is also reported to have abortifacient, uterotonic,
antimycobaterial, wound healing, hypotensive, myocardial
depressant and hypoglycemic activity.
Marker constituents: Vasicine
& Vasicinone.
Main uses : Bronchodilator, expectorant, uterotonic.
Specification: Vasicine,
Vasicinone >=1.0
| SL NO |
TESTS |
LIMITS |
PROTOCOL |
| 1. |
Description
|
Dark green to greenish brown powder. |
| 2. |
Physico-chemical analysis
|
|
|
| Moisture (%w/w) |
< 5.0 |
As per USP <921> Method II |
| Ash content (%w/w) |
< 30.0 |
As per USP<561>
Vegetable Drugs |
| Acid insoluble Ash (%w/w) |
< 2.0 |
| 3. |
Particle Size |
|
|
Particle Size
Bulk Density (g/cc) |
0.20 – 0.80 |
As per USP <616> Method –
I |
| Tapped Bulk Density (g/cc) |
|
| Material passing through 30# BS/35 ASTM (%w/w) |
> 99.0 |
As per USP <786>
Particle Size distribution. |
| 4. |
Heavy metal analysis |
|
AAS / ICP–ES |
| Lead |
< 10 ppm |
| Cadmium |
< 1 ppm |
| Arsenic |
< 2 ppm |
| Mercury |
< 0.1 ppm |
| 5. |
Microbiological analysis |
|
As per WHO/PHARMA/92.559/Rev.1 Pg.49-52 |
| As per FIP Guidelines |
|
| Total Viable Aerobic Count |
< 104 cfug-1 |
| Total Enterobacteriaceae |
< 102 org g-1 |
| Total Fungal Count |
< 102 fs g-1 |
| 6. |
Test for Specific Pathogen |
|
| As per FIP Guidelines |
|
| E.coli (1g) |
Absent |
| Salmonella Sp. (10g) |
Absent |
| S.aureus (1g) |
Absent |
| 7. |
Mycotoxin analysis |
<5ppb |
As per USP Test for Aflatoxins |
| Aflatoxins (B1 + B2 + G1 + G2) |
| 8. |
Residual solvent analysis |
<3000 ppm |
As per USP <467> |
| As per ICH Guidelines |
| Methanol |
| 9. |
Pesticide residue analysis |
To comply with
USP |
As per AOAC / USP |
| As per USP & BP Limits |
| Organochlorine Pesticides |
| Organophosphorus Pesticides |
| Synthetic pyrethroids |
| 10. |
Phytochemical analysis |
>= 1.0 |
By HPLC / HPTLC |
| Vasicine (%w/w) |
| Vasicinone (%w/w) |
|
